ea0003oc7 | Genetics: New Insights into Endocrine Disease | BES2002
Collins J
, Heward J
, Allahabadia A
, Franklyn J
, Gough S
, Nithiyananthan R
A number of candidate genes have been investigated as susceptibility loci for the development of Graves' disease. Those which appear to be consistently associated with disease include the HLA and the CTLA-4 gene regions. Polymorphisms of the VDR gene have been shown to increase susceptibility to autoimmune diseases including type 1 diabetes, multiple sclerosis, and Crohn's disease. Recently, an association has also been reported between the VDR gene and autoimmune thyroid dise...